Copies of the gene coding for the Mad2 protein

Suppose you have a human tissue culture line in which both normal copies of the gene coding for the Mad2 protein have been replaced by mutant gene copies, each of which contains the same temperature-sensitive mutation. The resulting mutant Mad2 protein folds and functions normally when the cells are maintained at 22°C, but the protein misfolds and is inactive when the cells are transferred to 37°C. Assume that all of the cells in this line are synchronous (i.e., they all pass through the same stages of the cell cycle in unison). If you shifted the cell population to 37°C sometime in G2, what plausible prediction could you make about the chromosomal makeup of at least some of the daughter cells generated by the subsequent mitoses? Briefly explain the basis of your prediction.