Elaborate on the anatomical and physiological basis of chronic pain syndromes

Elaborate on the anatomical and physiological basis of chronic pain syndromes such as fibromyalgia, incorporating an analysis of central sensitization, neuroinflammation, and dysfunctional pain modulation mechanisms. Discuss how alterations in neurotransmitter signaling, including glutamate, serotonin, and substance P, contribute to the amplification and persistence of pain perception in af

Elaborate on the anatomical and physiological basis of chronic pain syndromes such as fibromyalgia, incorporating an analysis of central sensitization, neuroinflammation, and dysfunctional pain modulation mechanisms. Discuss how alterations in neurotransmitter signaling, including glutamate, serotonin, and substance P, contribute to the amplification and persistence of pain perception in affected individuals. Furthermore, explore multimodal treatment approaches targeting neuroplastic changes, stress management, and sensory desensitization for improving functional outcomes in chronic pain patients.

fected individuals. Furthermore, explore multimodal treatment approaches targeting neuroplastic changes, stress management, and sensory desensitization for improving functional outcomes in chronic pain patients.