Lupus erythematosus

A 38-year-old female with a past medical history of significant lupus erythematosus (SLE) and hypertension, presents to her Primary Care Physician (PCP) for a wellness visit.  On physical exam, she is in no distress, VS BP 160/80mmHg (normally takes metoprolol and lisinopril but forgets from time to time) HR 80bpm RR 20/min.

Laboratory results show Hgb 14g/dl, WBC 5.0k, Platelets 160K, Cr. 1.80, eGFR 48ml/min.  She denies fevers and chills.  Denies diarrhea.  The patient is concerned about her elevated Cr and asks the PCP a few questions.

Q1:  Compare the etiology of Acute and Chronic Kidney Disease.

Q2:  Describe the mechanism for Acute Kidney Injury in Acute Tubular Necrosis.