The molecular mechanisms

Obstructive Uropathy & APSGN


The 5 General Topics of Disease Summary
1. Etiology & risk factors
2. Pathogenesis: The molecular mechanism of the disease process (How the disease process evolves)
3. Clinical Picture: Signs& Symptoms, Sequelae, and Complications
4. Diagnosis: Labs & tests (as well as screening tests and follow-up tests whenever applicable)
5. Pathophysiologic rationale of treatment


This summary should cover TWO TOPICS: Acute Post-Streptococcal Glomerulonephritis (APSGN)& Obstructive Uropathy.


Acute Post-Streptococcal Glomerulonephritis (APSGN):  IN PEDIATRIC PATIENTS

  1. Etiology:

Group A beta-hemolytic streptococcal infection followed by an autoimmune reaction.

  1. Pathogenesis:

The molecular mechanisms of the steps that follow the strept. Infection and leads to the development of glomerulonephritis as an autoimmune disorder.

  1. Clinical Picture:

Signs and symptoms of the condition and possible complications.

  1. Diagnosis:

Lab and other tests used to diagnose the condition.


Obstructive Uropathy:

  1. Etiology:

Talk about all the different causes that obstruct the urinary tract (stones, strictures, tumors, BPH)

Then focus on STONES & BPH

  1. Pathogenesis:

Talk about types of stones and the risk factors of developing these different types of stones.

Talk about BPH and the cellular/molecular mechanisms involved in the development of this condition

  1. Clinical Picture:

Signs & symptoms of urinary tract stones and BPH as well as their complications

  1. Diagnosis:

Labs & other tests to diagnose these two obstructive uropathy disorders

  1. The pathophysiologic rationale of treatment:

Especially for meds used for BPH

Please see the instructions attached. This is the textbook information McCance, K.L., Huether, S. E. (2018) Pathophysiology: The Biological Basis for Disease in Adults and Children. (8th Ed) St. Louis, MO. Elsevier Mosby ISBN-13: 978-0323583473 ISBN-10: 9780323583473