Bleeding and thrombotic Disorders
Summarize the bleeding and thrombotic disorders: platelet and coagulation disorders in terms of etiology, pathogenesis, clinical picture, diagnosis, and treatment rationale.
The 5 General Topics of Disease Summary |
1. Etiology & risk factors |
2. Pathogenesis: The molecular mechanism of the disease process (How the disease process evolves) |
3. Clinical Picture: Signs& Symptoms, Sequelae, and Complications |
4. Diagnosis: Labs & tests (as well as screening tests and follow up tests whenever applicable) |
5.Pathophysiologic rationale of treatment |
Platelet Disorders: Talk about TWO DISORDERS: Low platelet count (Thrombocytopenia), increased platelet count (Thrombocytosis)
- Thrombocytopenia:
- Etiology& Pathogenesis: different types of thrombocytopenia and what cause them, also talk about causes of defective platelet function including antiplatelet medication effects
- Clinical Picture: manifestations of low-platelet bleeding disorders. (in contrast to clotting factor deficiency bleeding disorder)
- Diagnosis: bleeding time, platelet count, Thromboelastography with platelet mapping.
- Pathophysiologic rationale of treatment: indications of platelet transfusion.
- Thrombocytosis:
- Etiology& Pathogenesis: as a part of myeloproliferative disorder (essential thrombocytosis)
- Clinical Picture: Signs& Symptoms of thrombocytosis and complications
- Diagnosis:
- Pathophysiologic rational of treatment:
Coagulation Disorders: Talk about TWO DISORDERS: Hypocoagulability (Coagulopathy) and Hypercoagulability.
- Hypocoagulability:
- Etiology& Pathogenesis: Acquired causes of bleeding tendency (other than genetic causes): including liver failure, uremia, vit K deficiency & warfarin overdose.
- Clinical Picture: manifestations of coagulopathy (in contrast to platelet disorder types of bleeding)
- Diagnosis: PT & PTT (how each can help diagnose extrinsic vs intrinsic pathway disorders)
- Pathophysiologic rationale of treatment:
- Hypercoagulabilty:
- Etiology& pathogenesis: Factor V Leiden, Protein C deficiency, Protein S deficiency, antiphospholipid syndrome.
- Clinical Picture: Complications of hypercoagulability
- Diagnosis:
- The pathophysiologic rationale of treatment.
This is the textbook for information:
McCance, K.L., Huether, S. E. (2018) Pathophysiology: The Biological Basis for Disease in Adults and Children. (8th Ed) St. Louis, MO. Elsevier Mosby ISBN-13: 978-0323583473 ISBN-10: 9780323583473