Chronic non-suppurative inflammation of synovial joints

Rheumatoid arthritis is a chronic non-suppurative inflammation of synovial joints. A genetic predisposition is strongly suspected (HLA DR1) . This leads to autoimmunity and the formation of immune complexes with LGM antibodies in the serum, the immune complexes are deposited in the synovial membrane and initiate self-perpetuating chronic granulomatous inflammation of the synovial membrane.

b. arthritis is generally characterized by pain swelling and limitation of joint movement. pain and stiffness, particularly in the morning, mark the beginning of the disease .it occurs due to cartilage being worn off and fibrosis of the capsule, etc changes.

c. Rheumatoid factor- It is not specific to rheumatoid arthritis. It is present even in individuals who are not having rheumatoid arthritis. however, it is one of the diagnostic criteria for rheumatoid arthritis. it is a protein by our immune system .it is an autoantibody. IgM is the most common rheumatoid factor.

D.As Rheumatoid arthritis is an autoimmune disorder, it releases pro-inflammatory cytokines, such as TNF, that damage the joint tissue in people with RA and can also lead to weight loss, muscle wasting, and weakness