Discuss the effects of decreased oxygen availability

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Chronic liver damage by excess alcohol consumption can lead to cirrhosis, a condition in which the liver becomes hypoxic. Discuss the effects of decreased oxygen availability in the liver on the catabolic pathways we have discussed (glycolysis, TCA cycle, urea cycle, beta-oxidation, oxidative phosphorylation) after an intermediate fast (1-2 days). In addition, alcoholics often suffer from deficiencies in many of the B vitamins. Discuss how this may further impact overall metabolism.

(Be sure to add biochemical details to your answer including specific points of regulation, functions of specific B vitamin-dependent enzymes and pathways, and interconnectedness of metabolic pathways. etc.)