Types of gene or protein families

What types of gene or protein families may be important for multicellularity?  Can we compare the genomes of different multicellular lineages like animals and plants to identify the most important genes critical for multicellularity?  Why or why not?

A gene family is a set of several similar genes, formed by duplication of a single original gene, that generally have similar biochemical functions. One such family are the genes for human haemoglobin subunits. The 10 genes are in two clusters on different chromosomes, called the α-globin and β-globin loci.