Randomized Controlled Trials (RCTs)

With regard to the people who participate in randomized controlled trials (RCTs), which of the following statements is true?

Eligibility criteria for RCTs often exclude patients with comorbidities.

RCTs are held in such high esteem that rates of participation are typically high.

Clinical patients are generally very similar to ones included in traditional RCTs.

RCTs often select as participants older patients, who might especially benefit from innovative Treatments