What specific type of cellular adaptation has taken place

Maria is a sedentary, 68-year-old woman who is overweight. She complains that her hands and feet are always cold, and she tires quickly when cleaning the house. At her most recent visit to her doctor, her blood pressure was 184/98 mm Hg. She has edema around her ankles and legs, and her physician is concerned about an echocardiogram that indicates Maria has an enlarged heart.

Initial response, answer the following three questions: Identify two reasons why Maria may have tissue ischemia. How might this lead to hypoxia? What are two changes that will occur in cells in response to hypoxia?    What specific type of cellular adaptation has taken place in Maria’s enlarged heart? What made you come to this conclusion?