Discuss the pathophysiological mechanisms involving peripheral sensitization

Explore the anatomical and physiological basis of chronic pain syndromes such as complex regional pain syndrome (CRPS) and neuropathic pain disorders. Discuss the pathophysiological mechanisms involving peripheral sensitization, central sensitization, and maladaptive neuroplastic changes in pain processing pathways. Furthermore, analyze the clinical manifestations and diagnostic criteria for CRPS and neuropathic pain, and evaluate multimodal treatment approaches incorporating pharmacotherapy, physical therapy, and psychological interventions for improving pain management and functional outcomes in affected individuals