Discuss the protective mechanisms involving epidermal keratinization

Elucidate the anatomical and physiological adaptations of the skin in response to environmental stressors such as ultraviolet (UV) radiation, temperature extremes, and microbial exposure. Discuss the protective mechanisms involving epidermal keratinization, melanin production, and sebum secretion, as well as the role of the skin microbiome in maintaining cutaneous immune surveillance and barrier function. Furthermore, explore the pathophysiology of skin conditions like sunburn, thermal burns, and infections, and evaluate preventive measures and treatment modalities for promoting skin health and integrity.