Explore the anatomical and physiological basis of the blood-brain barrier
Explore the anatomical and physiological basis of the blood-brain barrier (BBB) and its role in maintaining central nervous system (CNS) homeostasis. Discuss the specialized endothelial cells, tight junctions, and transport mechanisms that restrict the passage of molecules from the bloodstream into the brain parenchyma. Furthermore, analyze the implications of BBB dysfunction in neurological disorders such as Alzheimer’s disease, multiple sclerosis, and brain tumors, and evaluate emerging therapeutic strategies for enhancing drug delivery across the BBB.